Stress-induced reduction in reward-related prefrontal cortex function

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Stress-induced reduction in reward-related prefrontal cortex function

Acute psychological stress can trigger normal and abnormal motivated behaviors such as reward seeking, habitual behavior, and drug craving. Animal research suggests that such effects may result from actions of catecholamines and glucocorticoids that converge in brain regions that regulate motivated behaviors and incentive processing. At present, however, little is known about the acute effects ...

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The prefrontal cortex (PFC) plays a central role in processing both normal and pathological affective states and it is among the brain regions most closely associated with stress-related psychopathology in humans. The ventromedial PFC (vmPFC) in particular has been shown to be required for healthy emotional regulation, social function and risk assessment and decision-making. Also this region ex...

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INTRODUCTION Major depressive disorder (MDD) is often precipitated by life stress and growing evidence suggests that stress-induced alterations in reward processing may contribute to such risk. However, no human imaging studies have examined how recent life stress exposure modulates the neural systems that underlie reward processing in depressed and healthy individuals. METHODS In this proof-...

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p142: the prefrontal cortex and stress-related psychopathologies

the prefrontal cortex (pfc) plays a central role in processing both normal and pathological affective states and it is among the brain regions most closely associated with stress-related psychopathology in humans. the ventromedial pfc (vmpfc) in particular has been shown to be required for healthy emotional regulation, social function and risk assessment and decision-making. also this region ex...

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ژورنال

عنوان ژورنال: NeuroImage

سال: 2011

ISSN: 1053-8119

DOI: 10.1016/j.neuroimage.2010.11.068